Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation
نویسندگان
چکیده
منابع مشابه
Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation.
OBJECTIVE We used the hamster cheek pouch microcirculation to investigate the effects of melatonin (ME) on ischemia reperfusion (I-R) injury by in vivo microscopy. ME is a hormone produced by the pineal gland and is the most powerful and effective hydroxyl radical scavenger detected to date in vitro. The second aim was to determine the scavenger effect of ME in cheek pouch microcirculation when...
متن کاملEffects of Propionyl-L-Carnitine on Ischemia–Reperfusion Injury in Hamster Cheek Pouch Microcirculation
BACKGROUND AND PURPOSE Propionyl-l-carnitine (pLc) exerts protective effects in different experimental models of ischemia-reperfusion (I/R). The aim of the present study was to assess the effects of intravenously and topically applied pLc on microvascular permeability increase induced by I/R in the hamster cheek pouch preparation. METHODS The hamster cheek pouch microcirculation was visualize...
متن کاملAntioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheek pouch microcirculation.
Aspirin that has been chemically combined with a nitric oxide (NO) donor (NCX-4016) has been shown to inhibit cyclooxygenase and prostaglandin generation while maintaining the inhibitory effects of aspirin. The possible role of reactive oxygen species (ROS) in the action of NCX-4016 in ischemia-reperfusion (I/R) has not been studied. Furthermore, we were interested in comparing the effects of a...
متن کاملPreconditioning of the response to ischemia/reperfusion-induced plasma leakage in hamster cheek pouch microcirculation
OBJECTIVE Ischemic preconditioning and some drugs can protect tissues from injury by preserving microcirculation. This study evaluated vascular permeability in a hamster cheek pouch preparation using either short ischemic periods or bradykinin as preconditioning stimuli followed by 30 min of ischemia/reperfusion. METHOD Sixty-six male hamsters were divided into 11 groups: five combinations of...
متن کاملPropagated vasodilation in the microcirculation of the hamster cheek pouch.
Propagated vasodilation has been observed in the peripheral vasculature and may be significant in integrating the behavior of terminal arterioles and larger vessels. We have studied the characteristics of propagated vasodilation induced by acetylcholine in the microcirculation of the cheek pouch of the golden hamster. The technique of microionophoresis was used as a means of achieving relativel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1996
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(96)00030-2